Md Zafrul Hasan, Ph.D.
Principal Investigator
Molecular Immunology, HIV/AIDS, Alzheimer's, Lipid Metabolism, Bioinformatics
Biography
Dr. Hasan is a molecular immunologist with more than 12 years of research experience in infectious disease, neurobiology, autoimmunity, and lipid transporter biology. He received his Ph.D. in Medical Sciences and completed three postdoctoral trainings, building a strong and consistent scientific track record. His research expertise includes extensive work with mouse models, human primary cells, and cell culture systems. In addition, he has supervised and contributed to bioinformatics studies, including multiple projects focused on HIV, and has authored publications in public health. Dr. Hasan values collaborative science and has developed strong communication, presentation, and scientific writing skills through mentoring, teamwork, grant writing, and manuscript preparation.
Education
- Postdoctoral Fellow (Biochemistry), National University of Singapore: Singapore, SG (2021)
- Postdoctoral fellow (Sportology center), Juntendo Daigaku: Bunkyo-ku, Tokyo, JP (2014)
- Postdoctoral Fellow (Immune Signal Unit), Okinawa Institute of Science and Technology: Okinawa, JP (2017)
- Ph.D. in Medical Sciences, Kumamoto University, Japan (2012)
- MSc in Biochemistry and Molecular Biology, University of Dhaka (2003)
- BSc in Biochemistry and Molecular Biology, University of Dhaka (2002)
Active Research Projects
- A deep learning approach to explore immune pressure on HIV-1 Vif motifs
Previous Research Projects
- JunB protein as a biomarker in cancer diagnosis
- Polymorphism of HIV-1 Rev under immune pressure
Publications
| # | Title | Year | Journal |
|---|---|---|---|
| 1 | Impact of vitamin D deficiency on hyperlipidemia and hyperuricemia in pregnant women with gestational diabetes mellitus in Bangladesh | 2026 | BMC Endocrine Disorders |
| 2 | Predicting the evolutionary and structural compensation in Tat ARM region across HIV-1 groups using machine learning approach | 2026 | Scientific Reports |
| 3 | Opportunistic random blood glucose screening among professional drivers in northeastern Bangladesh: Assessing undiagnosed diabetes and health awareness | 2025 | PLOS Global Public Health |
| 4 | A computational exploration of global and temporal dynamics of selection pressure on HIV-1 Vif polymorphism | 2024 | Virus Research |
| 5 | Postnatal deletion of Spns2 prevents neuroinflammation without compromising blood vascular functions. | 2022 | Cellular and Molecular Life Sciences |
| 6 | Deletion of Mfsd2b impairs thrombotic functions of platelets. | 2021 | Nature Communications |
| 7 | Erythrocytes efficiently utilize exogenous sphingosines for S1P synthesis and export via Mfsd2b. | 2021 | The Journal of Biological Chemistry |
| 8 | Impact of Human Leukocyte Antigen-Associated Polymorphisms on Variability of HIV-1 Accessory and Regulatory Proteins. | 2021 | AIDS Research and Human Retroviruses |
| 9 | Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock | 2021 | Cell Reports |
| 10 | Prediction of immune pressure on HIV-1 regulatory gene tat by human host through bioinformatics tools | 2020 | J Adv Biotechnol Exp Ther |
| 11 | Deficiency of MFSD7c results in microcephaly-associated vasculopathy in Fowler syndrome. | 2020 | The Journal of Clinical Investigation |
| 12 | JunB is essential for IL-23-dependent pathogenicity of Th17 cells. | 2017 | Nature Communications |
| 13 | Region-specific vulnerability to oxidative stress, neuroinflammation, and tau hyperphosphorylation in experimental diabetes mellitus mice | 2016 | Journal of Alzheimer's Disease |
| 14 | Short-term treadmill exercise increased tau insolubility and neuroinflammation in tauopathy model mice | 2016 | Neuroscience Letters |
| 15 | CD8(+) T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope. | 2013 | PLOS ONE |
| 16 | Minor contribution of HLA class I-associated selective pressure to the variability of HIV-1 accessory protein Vpu | 2012 | Biochemical and Biophysical Research Communications |
| 17 | Naturally arising HIV-1 Nef variants conferring escape from cytotoxic T lymphocytes influence viral entry co-receptor expression and susceptibility to superinfection. | 2010 | Biochemical and Biophysical Research Communications |
Conferences
- 23rd SCAC: Selection pressure on HIV-1 Vif, Dhaka (2024)
- Spns2 deletion and EAE, NUS Singapore (2020)
Teaching
- Introductory Biochemistry
Awards & Recognition
- JRA Supporting Grant, Kumamoto University (2012)
- Global Health Travel Award, Keystone Symposium (2011)
- Monbukagakusho scholarship, Japan (2008)
Graduate Supervision
Current students: 05
Contact Information
Department of Biochemistry and Molecular Biology, SUST, Sylhet-3114, Bangladesh zafrul-bmb@sust.edu +8801706247124